三联疗法与序贯疗法在长期服用非甾体类抗炎药人群中根除幽门螺杆菌的疗效观察

黄鑫薪;陈旻湖;熊理守;马师洋;白鹏;董吁钢;杨岫岩;高修仁;梁柳琴;周丽雅

【期刊名称】《中华消化杂志》

【年(卷),期】2012(032)012

【摘要】目的 探讨长期服用非甾体类抗炎药(NSAID)的患者采用三联疗法与序贯疗法根除Hp的疗效.方法 以长期服用NSAID的患者为研究对象.将确诊的Hp感染者分为三联根除组和序贯根除组.三联根除组予埃索美拉唑+克拉霉素+阿莫西林治疗10 d;序贯根除组前5d予埃索美拉唑+阿莫西林,后5d予埃索美拉唑+克拉霉素+甲硝唑治疗.根除治疗结束后所有患者均予黏膜保护剂维持治疗,随访12周.随访前后行胃镜检查并检测Hp.对Hp根除率进行意向性分析和符合方案分析比较.结果 意向性分析显示,三联根除组和序贯根除组的Hp根除率分别为78.4％(40/51)和80.0％(40/50),两组差异无统计学意义(x2=0.038,P=0.846).符合方案分析显示,三联根除组和序贯根除组的Hp根除率分别为84.4％(38/45)和87.0％(40/46),两组差异无统计学意义(x2=0.117,P=0.732).结论 长期服用NSAID的患者采用三联疗法与序贯疗法根除Hp的疗效无显著差异.%Objective To explore the efficacy of triple therapy and sequential therapy in the eradication of Helicobacter pylori (Hp) in patients receiving long-term non-steroidal antiinflammatory drugs (NSAID) treatment.Methods Patients receiving long-term NSAID treatment were enrolled in this study.Patients diagnosed as Hp infection were divided into triple therapy and sequential therapy groups.The patients in triple therapy group received omeprazole,clarithromycin and amoxicillin theray for 10 days.The patients in sequential group received esomeprazole with amoxicillin for five days,and then esomeprazole with clarithromycin and metronidazole for another five days.All patients were given mucosal protective therapy as maintenance treatment after eradication therapy and followed up for 12 weeks.Patients underwent endoscopy examination and Hp testing before and after follow-up.Hp eradication rates were compared with the intention-to-treat (ITT) and per protocol (PP) analysis.Results According to ITT analysis,the eradication rates of Hp in triple therapy group and sequential therapy group were 78.4 ％ (40/51) and 80.0 ％ (40/50) respectively,there was no significant difference between these two groups (x2 =0.038,P=0.846).According to PP analysis,the eradication rates of Hp in triple therapy group and sequential therapy group were 84.4％ (38/45) and 87.0％ (40/46) respectively,there was no significant difference between these two groups either (x2=0.117,P=0.732).Conclusion There was no significant difference in Hp eradication between triple therapy and sequential therapy in patients receiving long-term NSAID treatment.

【总页数】4页(814-817)

【关键词】抗炎药,非甾体;螺杆菌,幽门;药物疗法,联合

【作者】黄鑫薪;陈旻湖;熊理守;马师洋;白鹏;董吁钢;杨岫岩;高修仁;梁柳琴;周丽雅

【作者单位】510080广州,中山大学附属第一医院消化科;510080广州,中山大学附属第一医院消化科;510080广州,中山大学附属第一医院消化科;510080广州,中山大学附属第一医院消化科;北京大学第三医院消化科;510080广州,中山大学附属第一医院心血管科;510080广州,中山大学附属第一医院风湿免疫科;510080广州,中山大学附属第一医院心血管科;510080广州,中山大学附属第一医院风湿免疫科;北京大学第三医院消化科

【正文语种】中文

【中图分类】

【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-digestion_thesis/0201232712371.html

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三联疗法与序贯疗法在长期服用非甾体类抗炎药人群中根除幽门螺杆