6-(4-Methoxyphenyl)-3-pyridazinamine - GABAA受体拮抗剂 - 4776-87-8 - Apexbio

发布时间：2018-02-01 09:49:59

修订日期: 6/30/2016产品说明书化学性质产品名: 6-(4-Methoxyphenyl)-3-pyridazinamineCas No.: 4776-87-8//struct//分子量: 201.2分子式: C11H11N3O化学名: 6-(4-methoxyphenyl)-3-pyridazinamineSMILES: NC1=NN=C(C2=CC=C(OC)C=C2)C=C1溶解性: Soluble in DMSO储存条件: Store at -20°C一般建议: For obtaining a higher solubility , please warm the tube at 37°Cand shake it in the ultrasonic bath for a while.Stock solution can bestored below -20°C for several months.运输条件: Evaluation sample solution : ship with blue iceAll other available size: ship with RT , or blue ice upon request生物活性靶点: Membrane Transporter/Ion Channel信号通路: GABA Receptor产品描述:6-(4-Methoxyphenyl)-3-pyridazinamine is a GABAA receptor antagonist.Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influence on target neurons. These receptors are the major targets for benzodiazepines and related anxiolytic drugs.In vitro: 6-(4-Methoxyphenyl)-3-pyridazinamine is an intermediate in the synthesis of SR 95103[2-(3-carboxypropyl)-3-amino-4-methyl-6-phenylpyridazinium chloride]. SR 95103 was identifiedas a selective and competitive GABA-A receptor antagonist. Moreover, SR 95103 was shown to be

6-(4-Methoxyphenyl)-3-pyridazinamine - GABAA受体拮抗剂 - 4776-87-8 - Apexbio

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